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Mol Cell. 2015 Jun 18;58(6):972-3. doi: 10.1016/j.molcel.2015.06.005.

Bending Forks and Wagging Dogs--It's about the DNA 3' Tail.

Author information

1
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
2
Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jatainer@lbl.gov.

Abstract

Protecting, reversing, and remodeling stalled replication forks are critical to genome stability and require coordinating DNA replication, remodeling, and repair. In this issue, Kile et al. (2015) find that unexpected HLTF specificity for DNA's 3'-hydroxyl tail helps control these biological functions.

PMID:
26091346
PMCID:
PMC5356400
DOI:
10.1016/j.molcel.2015.06.005
[Indexed for MEDLINE]
Free PMC Article

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