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Mol Cell. 2015 Jun 18;58(6):959-69. doi: 10.1016/j.molcel.2015.01.037.

RNA Regulation by Poly(ADP-Ribose) Polymerases.

Author information

1
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.
2
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.
3
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Electronic address: pchang2@mit.edu.

Abstract

Posttranscriptional regulation of RNA facilitates the fine-tuning of gene expression. It occurs through multiple pathways that include the nuclear processing of mRNA and its precursors, mRNA silencing, regulation of mRNA decay, and regulation of translation. Poly(ADP-ribose) polymerases (PARPs), enzymes that modify target proteins with ADP-ribose, play important roles in many of the RNA regulatory pathways through multiple mechanisms. For example, RNA-binding PARPs can target specific transcripts for regulation; ADP-ribosylation of RNA-regulatory proteins can alter their localization, activity, or RNA binding; and noncovalent interactions of RNA-binding proteins with poly(ADP-ribose) can affect their function. In addition to regulating RNA during non-stress conditions, PARPs regulate RNA function during cellular stress conditions that are critical for the proper execution of a stress response. In this review, we summarize the current knowledge regarding PARP-dependent regulation of RNAs, and describe how by modulating RNA processing, translation, and decay PARPs impact multiple processes in the cell.

PMID:
26091344
PMCID:
PMC4475274
DOI:
10.1016/j.molcel.2015.01.037
[Indexed for MEDLINE]
Free PMC Article

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