Cooperation for Better Inhibiting

Chem Biol. 2015 Jun 18;22(6):685-6. doi: 10.1016/j.chembiol.2015.06.002.

Abstract

Cladosporin is an antimalarial drug that acts as an ATP-mimetic to selectively inhibit Plasmodium lysyl-tRNA synthetase. Using multiple crystal structures, Fang et al. (2015) reveal in this issue of Chemistry & Biology the fascinating mechanism responsible for cladosporin selectivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Amino Acyl-tRNA Synthetases / metabolism*
  • Humans

Substances

  • Adenosine Triphosphate
  • Amino Acyl-tRNA Synthetases