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J Immunol Res. 2015;2015:501361. doi: 10.1155/2015/501361. Epub 2015 May 18.

Interactions between Innate Immunity, Microbiota, and Probiotics.

Author information

1
Digestive Endoscopy & Nutrition Unit, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
2
Division of Internal Medicine and Gastroenterology, "Cristo Re" Hospital, Via delle Calasanziane 25, 00167 Rome, Italy.
3
Clinical Nutrition Unit, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
4
Clinical Nutrition Unit, "Umberto I" Hospital, Viale del Policliniuco 185, 00186 Rome, Italy.
5
Division of Internal Medicine, "S. Eugenio" Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
6
Division of Gastroenterology, ASL Roma H, Via Borgo Garibaldi 12, Albano Laziale, 00041 Rome, Italy.
7
Division of Gastroenterology, "S. Paolo" Hospital, Contrada Capo Scardicchio 82, 00123 Bari, Italy.
8
Division of General Surgery, "P. Colombo" Hospital, ASL Roma H, Via Orti Ginnetti 7, Velletri, 00049 Rome, Italy.
9
Gastroenterology Service, ASL BAT, Via Torino 49, 76123 Andria, Italy.

Abstract

The term "microbiota" means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such as α/β defensins, cathelicidin, 14 β-glycosidases, C-type lectins, and ribonuclease, in response to various stimuli. Recent studies found probiotics able to preserve intestinal homeostasis by downmodulating the immune response and inducing the development of T regulatory cells. Specific probiotic strain, as well as probiotic-driven metabolic products called "postbiotics," has been recently recognized and it is able to influence innate immunity. New therapeutic approaches based on probiotics are now available, and further treatments based on postbiotics will come in the future.

PMID:
26090492
PMCID:
PMC4451779
DOI:
10.1155/2015/501361
[Indexed for MEDLINE]
Free PMC Article

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