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Exp Biol Med (Maywood). 2015 Aug;240(8):1099-106. doi: 10.1177/1535370215591828. Epub 2015 Jun 18.

Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues.

Author information

1
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
2
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China libj@sjtu.edu.cn.

Abstract

The aging population and the incidence of aging-related diseases such as osteoporosis are on the rise. Aging at the tissue and organ levels usually involves tissue stem cells. Human and animal model studies indicate that aging affects two aspects of mesenchymal stem cell (MSC): a decrease in the bone marrow MSC pool and biased differentiation into adipocyte at the cost of osteoblast, which underlie the etiology of osteoporosis. Aging of MSC cells is also detrimental to some non-skeletal tissues, in particular the hematopoietic system, where MSCs serve as a niche component. In addition, aging compromises the therapeutic potentials of MSC cells, including cells isolated from aged individuals or cells cultured for many passages. Here we discuss the recent progress on our understanding of MSC aging, with a focus on the effects of MSC aging on bone remodeling and hematopoiesis and the mechanisms of MSC aging.

KEYWORDS:

Mesenchymal stem cells; aging; biased differentiation; bone remodeling; hematopoietic stem cell; niche; osteoporosis

PMID:
26088863
PMCID:
PMC4935286
DOI:
10.1177/1535370215591828
[Indexed for MEDLINE]
Free PMC Article

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