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Expert Rev Gastroenterol Hepatol. 2015;9(8):1069-76. doi: 10.1586/17474124.2015.1057122. Epub 2015 Jun 18.

Is intestinal inflammation linking dysbiosis to gut barrier dysfunction during liver disease?

Author information

1
Skaggs School of Pharmacy, University of California San Diego, 9500 Gilman Drive La Jolla, California.

Abstract

Changes in the intestinal microbiota composition contribute to the pathogenesis of many disorders including gastrointestinal and liver diseases. Recent studies have broadened our understanding of the "gut-liver" axis. Dietary changes, other environmental and genetic factors can lead to alterations in the microbiota. Dysbiosis can further disrupt the integrity of the intestinal barrier leading to pathological bacterial translocation and the initiation of an inflammatory response in the liver. In this article, the authors dissect the different steps involved in disease pathogenesis to further refine approaches for the medical management of liver diseases. The authors will specifically discuss the role of dysbiosis in inducing intestinal inflammation and increasing intestinal permeability.

KEYWORDS:

bacterial translocation; gut-liver axis; intestinal barrier; intestinal inflammation; metabolome; metagenome; microbiome

PMID:
26088524
PMCID:
PMC4828034
DOI:
10.1586/17474124.2015.1057122
[Indexed for MEDLINE]
Free PMC Article

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