Format

Send to

Choose Destination
Gut Liver. 2016 Mar;10(2):275-82. doi: 10.5009/gnl14391.

Factors Influencing the Diagnostic Accuracy of Acoustic Radiation Force Impulse Elastography in Patients with Chronic Hepatitis B.

Park MS1, Kim SW1, Yoon KT2, Kim SU1,3,4, Park SY5, Tak WY5, Kweon YO5, Cho M2, Kim BK1,3,4, Park JY1,3,4, Kim DY1,3,4, Ahn SH1,3,4,6, Han KH1,3,4,6.

Author information

1
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
2
Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea.
3
Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
4
Liver Cirrhosis Clinical Research Center, Seoul, Korea.
5
Department of Gastroenterology and Hepatology, Kyungpook National University, Daegu, Korea.
6
Brain Korea 21 Project for Medical Science, Seoul, Korea.

Abstract

BACKGROUND/AIMS:

To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB).

METHODS:

Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from November 2010 to March 2013 were prospectively recruited from three tertiary hospitals.

RESULTS:

We analyzed 105 patients (median age of 47 years). The F0-1, F2, F3, and F4 fibrosis stages were identified in 27 (25.7%), 27 (25.7%), 21 (20.0%), and 30 (28.6%) patients, respectively. The areas under the receiver operating characteristics curves for ARFI elastography in assessing ≥ F2, ≥ F3, and F4 was 0.814, 0.848, and 0.752, respectively. The discordance of at least one stage between LB and ARFI was observed in 68 patients (64.8%) and of at least two stages in 16 patients (15.2%). In a multivariate analysis, advanced fibrosis stage (F3-4) was the only factor that was negatively correlated with one-stage discordance (p=0.042). Moreover, advanced fibrosis stage was negatively (p=0.016) correlated and body mass index (BMI) was positively (p=0.006) correlated with two-stage discordance.

CONCLUSIONS:

Advanced fibrosis stage (F3-4) was a predictor of nondiscordance between LB and ARFI elastography; BMI also influenced the accuracy of ARFI elastography.

KEYWORDS:

Acoustic radiation force impulse; Discordance; Hepatitis B, chronic; Liver cirrhosis

PMID:
26087790
PMCID:
PMC4780458
DOI:
10.5009/gnl14391
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Inforang Icon for PubMed Central
Loading ...
Support Center