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J Perinatol. 2015 Sep;35(9):678-82. doi: 10.1038/jp.2015.66. Epub 2015 Jun 18.

Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring.

Chen LM1,2,3, Chen QS4, Jin GX5, Si GX6, Zhang Q7, Ye EL1,2,3, Yang H1,2,3, Cai LQ1,2,3, Peng MM1,2,3, Lin ZZ1,2,3, Yu LC1,2,3, Zhang C2,3, Lu XM1,2,3.

Author information

1
Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.
2
Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
3
Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
4
Department of Endocrinology, Wenzhou People's Hospital, Wenzhou, China.
5
Department of Pediatrics, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.
6
Department of Endocrinology, Jining First People's Hospital, Jining, China.
7
ICU, Taizhou First People's Hospital, Taizhou, China.

Abstract

OBJECTIVE:

To evaluate the effects of gestational subclinical hypothyroidism (SCH) on early neurodevelopment of offspring.

STUDY DESIGN:

A prospective study included 106 infants born to mothers with gestational SCH and 106 infants born to mothers who were euthyroid during pregnancy. The neurodevelopment of 12 to 24-month-old infants was assessed and compared using the Gesell developmental test (revised version).

RESULTS:

Infants born to mothers with gestational SCH and those born to euthyroid mothers had similar scores on the Gesell development test. No correlations were observed between maternal TSH concentration and Gesell developmental test scores of offspring. Infants born to mothers who had gestational SCH during the first trimester specifically and those born to euthyroid mothers had similar scores on the Gesell development test. No significant correlations were detected between maternal TSH concentration during the first trimester and offspring neurodevelopment.

CONCLUSIONS:

No detectable neurodevelopment deficit was observed in offspring up to 24 months old from mothers who had gestational SCH.

PMID:
26087317
DOI:
10.1038/jp.2015.66
[Indexed for MEDLINE]

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