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Cell Death Dis. 2015 Jun 18;6:e1792. doi: 10.1038/cddis.2015.162.

T-cell exhaustion in the tumor microenvironment.

Author information

1
Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
2
1] Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China [2] Center for Experimental Therapeutics and Reperfusion Injury, Perioperative and Pain Medicine, Harvard Institutes of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Abstract

T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials.

PMID:
26086965
PMCID:
PMC4669840
DOI:
10.1038/cddis.2015.162
[Indexed for MEDLINE]
Free PMC Article

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