Format

Send to

Choose Destination
Circulation. 2015 Aug 18;132(7):578-85. doi: 10.1161/CIRCULATIONAHA.115.016537. Epub 2015 Jun 17.

Circulating Biomarkers and Abdominal Aortic Aneurysm Incidence: The Atherosclerosis Risk in Communities (ARIC) Study.

Author information

1
From Division of Epidemiology and Community Health, School of Public Health (A.R.F., L.Y., A.A., P.L.L., W.T.), Division of Cardiology, Department of Medicine, School of Medicine (E.M.), and Department of Medicine, School of Medicine (F.A.L.), University of Minnesota, Minneapolis; Minneapolis VA Health Care System, MN (F.A.L.); and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Houston Methodist DeBakey Heart and Vascular Center, TX (C.M.B.). folso001@umn.edu.
2
From Division of Epidemiology and Community Health, School of Public Health (A.R.F., L.Y., A.A., P.L.L., W.T.), Division of Cardiology, Department of Medicine, School of Medicine (E.M.), and Department of Medicine, School of Medicine (F.A.L.), University of Minnesota, Minneapolis; Minneapolis VA Health Care System, MN (F.A.L.); and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Houston Methodist DeBakey Heart and Vascular Center, TX (C.M.B.).

Abstract

BACKGROUND:

The pathogenesis of abdominal aortic aneurysm (AAA) is complex. Cross-sectional studies have connected circulating biomarkers with AAA, but prospective evidence is limited.

METHODS AND RESULTS:

In the Atherosclerosis Risk in Communities Study cohort, we measured multiple blood biomarkers of inflammation, hemostasis, thrombin generation, cardiac dysfunction, and vascular stiffness and identified incident AAAs during follow-up using hospital discharge codes. Six biomarkers (white blood cell count, fibrinogen, D-dimer, troponin T, N-terminal pro-brain natriuretic peptide, and high-sensitivity C-reactive protein) were strongly associated positively with AAA incidence. Compared with having none of these 6 biomarkers in the highest quartile, the hazard ratios of AAA for those with 1, 2, 3, or 4 to 6 biomarkers in the highest quartile were 2.2, 3.3, 4.0, and 9.9, respectively (P for trend < 0.0001) after adjustment for other risk factors.

CONCLUSIONS:

This prospective study found that higher concentrations of 6 biomarkers were associated with increased risk of AAA. The more markers that fell into the highest quartile, the higher the AAA risk was. Multiple positive biomarkers identify a subgroup of patients at high risk of AAA.

KEYWORDS:

aortic aneurysm, abdominal; cohort studies; risk factors

PMID:
26085454
PMCID:
PMC4543558
DOI:
10.1161/CIRCULATIONAHA.115.016537
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center