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Macromol Biosci. 2015 Oct;15(10):1365-74. doi: 10.1002/mabi.201500142. Epub 2015 Jun 17.

Polymer-Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells.

Author information

1
CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. mancarella.serena@gmail.com.
2
CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. valegre86@hotmail.it.
3
CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. frabal84@alice.it.
4
Dipartimento di Beni Culturali, Università del Salento, via Dalmazio Birago 64, 73100, Lecce, Italy. frabal84@alice.it.
5
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Campus Ecotekne, S.P. 6, Lecce-Monteroni, Lecce, Italy. danielevergara@libero.it.
6
Laboratory of Clinical Proteomic, "Giovanni Paolo II" Hospital, ASL-Lecce, Italy. danielevergara@libero.it.
7
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Campus Ecotekne, S.P. 6, Lecce-Monteroni, Lecce, Italy. michele.maffia@unisalento.it.
8
Laboratory of Clinical Proteomic, "Giovanni Paolo II" Hospital, ASL-Lecce, Italy. michele.maffia@unisalento.it.
9
CNR NANOTEC - Istituto di Nanotecnologia, Polo di Nanotecnologia c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy. stefano.leporatti@nanotec.cnr.it.

Abstract

The new goal of anticancer agent research is the screening of natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in the Indian cuisine. The molecule has high pleiotropic activities including strong antioxidant and anti-inflammatory properties. However, its clinical potential is limited due its low solubility and bioavailability. We have developed a layer by layer functionalization of Fe3 O4 nanoparticles (nano-Fe3 O4 ) by coating biodegradable polyelectrolyte multilayers such as Dextran (DXS) and Poly(l-lysine) (PLL). Physico-chemical studies were performed to obtain a high upload of curcumin in Fe3 O4 nanoparticles. Nano-Fe3 O4 were then tested against an ovarian cancer cell line, SKOV-3, to demonstrate their therapeutic efficacy.

KEYWORDS:

cancer; curcumin; drug delivery; nanoparticles; polymer

PMID:
26085082
DOI:
10.1002/mabi.201500142
[Indexed for MEDLINE]

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