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Eur J Appl Physiol. 2015 Oct;115(10):2215-22. doi: 10.1007/s00421-015-3202-0. Epub 2015 Jun 18.

Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responses.

Author information

1
School of Sport Science, Exercise and Health (M408), The University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia. claire.badenhorst@research.uwa.edu.au.
2
School of Sport Science, Exercise and Health (M408), The University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia.
3
Sports Nutrition, Australian Institute of Sport, Gold Coast, Queensland, Australia.
4
Department of Laboratory Medicine (TML 830), Radboud University Medical Center, Nijmegen, The Netherlands.
5
Hepcidinanalysis.com, Geert Grooteplein 10 (830), 6525 GA, Nijmegen, The Netherlands.

Abstract

PURPOSE:

Carbohydrate ingestion prior and during exercise attenuates exercise-induced interleukin-6. This investigation examined if an analogous effect was evident for interleukin-6 and hepcidin response when carbohydrates were ingested post-exercise.

METHODS:

In a crossover design, 11 well-trained endurance athletes completed two experimental trials. Participants completed an 8 × 3 min interval running session at 85 % vVO2peak followed by 5 h of monitored recovery. During this period, participants were provided with two 1.2 g kg(-1) carbohydrate beverages at either an early feeding time (immediately post-exercise and 2 h post-exercise) or delayed feeding time (2 h post-exercise and 4 h post-exercise). Venous blood samples were collected pre-, immediately post-, 3 and 5 h post-exercise. Samples were analysed for Interleukin-6, serum iron, serum ferritin and hepcidin.

RESULTS:

Interleukin-6 was significantly elevated (p = 0.004) immediately post-exercise compared to baseline for both trials. Hepcidin levels were significantly elevated at 3 h post-exercise (p = 0.001) and 5 h post-exercise (p = 0.002) compared to baseline levels in both trials, with no significant difference between the two conditions and any time point. Serum iron was significantly increased from baseline to immediately post-exercise (p = 0.001) for both trials, with levels decreasing by 3 h (p = 0.025) and 5 h post-exercise (p = 0.001). Serum ferritin levels increased immediately post-exercise compared to baseline (p = 0.006) in both conditions.

CONCLUSIONS:

The timing and ingestion of post-exercise carbohydrate ingestion do not appear to impact post-exercise interleukin-6 and hepcidin responses; this is likely a result of the interval running task inducing an inflammatory response and subsequent up-regulation of hepcidin.

KEYWORDS:

Cytokine; Interval running; Iron metabolism; Nutrition

PMID:
26084589
DOI:
10.1007/s00421-015-3202-0
[Indexed for MEDLINE]

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