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Clin Infect Dis. 2015 Oct 15;61(8):1304-6. doi: 10.1093/cid/civ474. Epub 2015 Jun 16.

Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir.

Author information

1
Division of Infectious Diseases, Department of Medicine.
2
Department of Medicine.
3
Division of Infectious Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.
4
Division of Digestive Diseases, Department of Medicine Emory Transplant Center, Emory University School of Medicine.
5
Division of Digestive Diseases, Department of Medicine Atlanta Veterans Affairs Medical Center, Georgia.

Abstract

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

KEYWORDS:

HBV reactivation; HBV/HCV coinfection; acute hepatitis; simeprevir; sofosbuvir

PMID:
26082511
DOI:
10.1093/cid/civ474
[Indexed for MEDLINE]

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