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J Neurol Sci. 2015 Aug 15;355(1-2):180-5. doi: 10.1016/j.jns.2015.06.014. Epub 2015 Jun 10.

Toll like receptor-4 gene polymorphisms in patients with solitary cysticercus granuloma.

Author information

1
Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India.
2
Department of Neurology, King George Medical University, Uttar Pradesh, Lucknow, India. Electronic address: garg50@yahoo.com.
3
Department of Microbiology, King George Medical University, Uttar Pradesh, Lucknow, India.

Abstract

BACKGROUND:

Solitary cysticercus granuloma (SCG) of the brain is the most common type of neurocysticercosis in India. In this study, we evaluated TLR4 polymorphisms in patients with SCG.

METHODS:

One-hundred-forty-three patients with SCG and 134 controls were enrolled. Assessment for TLR4 Asp299Gly and Thr399Ile polymorphism was done. TLR4 genotype was determined by PCR-sequencing chain termination method. The patients were followed for 6 months.

RESULTS:

Asp/Gly (P=0.024) and Thr/Ile (P=0.004) genotypes were significantly associated with the SCG. The Gly (Asp/Gly plus Gly/Gly) genotype (P=0.025) and Ile (Thr/Ile plus Ile/Ile) genotype (P=0.008) were significantly associated with the SCG. Gly/Gly and Ile/Ile genotypes were not significantly associated with SCG (P=0.767 for Gly/Gly, P=0.936 for Ile/Ile). At 6 months, TLR4 299Asp/Gly (P=0.02) and 399Ile/Thr (P=0.023) polymorphisms were significantly associated with the calcification or persistence of SCG.

CONCLUSIONS:

TLR4 polymorphisms are associated with the susceptibility to infection with SCG.

KEYWORDS:

Cysticercosis; Innate immunity; Neurocysticercosis; Ring enhancing lesion; Seizures; Toll-like receptors

PMID:
26081118
DOI:
10.1016/j.jns.2015.06.014
[Indexed for MEDLINE]

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