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Exp Gerontol. 2015 Sep;69:148-58. doi: 10.1016/j.exger.2015.06.010. Epub 2015 Jun 14.

Effects of resistance training on testosterone metabolism in younger and older men.

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Department of Biology of Physical Activity, University of Jyväskylä, Finland. Electronic address:
Department of Cardiology, Central Hospital, Jyväskylä, Finland.
Department of Physiology, University of Turku, Finland; Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, UK.
Department of Clinical Physiology, Central Hospital, Jyväskylä, Finland.
Department of Gynecology, Central Hospital, Jyväskylä, Finland.
Department of Urology, University of Helsinki, Finland.
The Department of Human Sciences, The Ohio State University, USA.
Department of Biology of Physical Activity, University of Jyväskylä, Finland.


This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n=5, 28±3yrs.) and older (n=8, 70±2yrs.) men. Experimental heavy resistance exercises (5×10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p<0.05-0.01). This study further showed that RT may have acute effect on T production and clearance rates, while the exercise-induced increases in serum T appeared to be induced by decreased metabolic clearance rate of T. Attenuated T production capacity and urinary excretion of T metabolites in older men may reflect the known reduction in testicular steroidogenesis upon aging. No changes were observed in T metabolism due to RT indicating a homeostatic stability for this hormone in men of different ages.


Androgen receptor; Androsterone; Etiocholanolone; GnRH; Luteinizing hormone

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