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Exp Gerontol. 2015 Sep;69:148-58. doi: 10.1016/j.exger.2015.06.010. Epub 2015 Jun 14.

Effects of resistance training on testosterone metabolism in younger and older men.

Author information

1
Department of Biology of Physical Activity, University of Jyväskylä, Finland. Electronic address: juha.ahtiainen@jyu.fi.
2
Department of Cardiology, Central Hospital, Jyväskylä, Finland.
3
Department of Physiology, University of Turku, Finland; Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, UK.
4
Department of Clinical Physiology, Central Hospital, Jyväskylä, Finland.
5
Department of Gynecology, Central Hospital, Jyväskylä, Finland.
6
Department of Urology, University of Helsinki, Finland.
7
The Department of Human Sciences, The Ohio State University, USA.
8
Department of Biology of Physical Activity, University of Jyväskylä, Finland.

Abstract

This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n=5, 28±3yrs.) and older (n=8, 70±2yrs.) men. Experimental heavy resistance exercises (5×10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p<0.05-0.01). This study further showed that RT may have acute effect on T production and clearance rates, while the exercise-induced increases in serum T appeared to be induced by decreased metabolic clearance rate of T. Attenuated T production capacity and urinary excretion of T metabolites in older men may reflect the known reduction in testicular steroidogenesis upon aging. No changes were observed in T metabolism due to RT indicating a homeostatic stability for this hormone in men of different ages.

KEYWORDS:

Androgen receptor; Androsterone; Etiocholanolone; GnRH; Luteinizing hormone

PMID:
26079649
DOI:
10.1016/j.exger.2015.06.010
[Indexed for MEDLINE]

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