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Alzheimers Dement. 2016 Jan;12(1):75-84. doi: 10.1016/j.jalz.2015.04.008. Epub 2015 Jun 13.

Development of a patient-reported outcome instrument to assess complex activities of daily living and interpersonal functioning in persons with mild cognitive impairment: The qualitative research phase.

Author information

1
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA. Electronic address: mark.gordon@boehringer-ingelheim.com.
2
Evidera, formerly United BioSource Corporation (UBC), Lexington, MA, USA.
3
Xcenda, Palm Harbor, FL, USA.
4
Merck, Kenilworth, NJ, USA.
5
Outcometrix, Tucson, AZ, USA.
6
Bracket, Wayne, PA, USA.
7
Genentech, South San Francisco, CA, USA.
8
Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
9
University of California, San Diego, School of Medicine, San Diego, CA, USA.
10
McGill Centre for Studies in Aging, Montreal, Canada.
11
Patient-Centered Outcomes Research Institute (PCORI), Washington, D.C, USA.

Abstract

INTRODUCTION:

As drug development research efforts move toward studying patients earlier in the course of Alzheimer's disease (AD), it is important to incorporate the patient's perspective into measurement of outcomes.

METHODS:

This article summarizes the qualitative work of the Patient-Reported Outcome Consortium's Cognition Working Group in the development of a new self-reported outcome measure in persons with mild cognitive impairment (MCI) due to suspected AD, herein referred to as MCI.

RESULTS:

The draft measure captures the patient's voice for two functional domains, complex activities of daily living and interpersonal functioning.

DISCUSSION:

This work represents a series of initial steps in the development of this rating scale. The next steps are to conduct psychometric analysis and evaluate the role of insight.

KEYWORDS:

Activities of daily living; Alzheimer's disease; Cognition; Critical Path Institute; Interpersonal functioning; Mild cognitive impairment; Patient-reported outcome; Qualitative

PMID:
26079412
DOI:
10.1016/j.jalz.2015.04.008
[Indexed for MEDLINE]

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