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Alzheimers Dement. 2016 Apr;12(4):380-90. doi: 10.1016/j.jalz.2015.05.013. Epub 2015 Jun 13.

The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B.

Author information

1
Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
2
Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
3
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
4
Waisman Center, University of Wisconsin Madison, Madison, WI, USA.
5
Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA.
6
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
7
Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA.
8
New York State Institute for Basic Research in Developmental Disabilities, Albany, NY, USA.
9
Department of Medicine-Geriatrics, University of Wisconsin Madison, Madison, WI, USA.
10
Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin Madison, Madison, WI, USA. Electronic address: bchristian@wisc.edu.

Abstract

INTRODUCTION:

In Down syndrome (DS), the overproduction of amyloid precursor protein is hypothesized to predispose young adults to early expression of Alzheimer-like neuropathology.

METHODS:

PET imaging with carbon 11-labeled Pittsburgh compound B examined the pattern of amyloid-β deposition in 68 nondemented adults with DS (30-53 years) to determine the relationship between deposition and normal aging. Standard uptake value ratio (SUVR) images were created with cerebellar gray matter as the reference region.

RESULTS:

Multiple linear regression revealed slight but highly significant (corrected P < .05) positive correlations between SUVR and age. The striatum showed the strongest correlation, followed by precuneus, parietal cortex, anterior cingulate, frontal cortex, and temporal cortex.

CONCLUSION:

There is an age-related amyloid-β deposition in the DS population, but as a pattern of elevated cortical retention becomes apparent, the correlation of SUVR with age ceases to be significant. Factors unrelated to aging may drive an increase in deposition during early Alzheimer's disease pathogenesis.

KEYWORDS:

Aging; Alzheimer's disease; Amyloid imaging; Down syndrome; PiB

PMID:
26079411
PMCID:
PMC4677061
DOI:
10.1016/j.jalz.2015.05.013
[Indexed for MEDLINE]
Free PMC Article

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