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Sci Rep. 2015 Jun 16;5:11355. doi: 10.1038/srep11355.

Cytokine profile in severe Gram-positive and Gram-negative abdominal sepsis.

Author information

1
1] Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Crnotravska 17, Belgrade 11000, Serbia [2] Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Crnotravska 17, Belgrade 11000, Serbia.
2
1] School of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia [2] Clinical Center of Serbia, Pasterova 2, Belgrade 11000, Serbia.
3
1] Institute for Medical Research, Military Medical Academy, Crnotravska 17, Belgrade 11000, Serbia [2] Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Crnotravska 17, Belgrade 11000, Serbia.
4
Clinical Center of Serbia, Pasterova 2, Belgrade 11000, Serbia.
5
1] Clinical Center Kragujevac, Zmaj Jovina 30, Kragujevac 34000, Serbia [2] Faculty of Medical Sciences University of Kragujevac, Svetozara Markovica 69,Kragujevac 34000, Serbia.
6
1] Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Crnotravska 17, Belgrade 11000, Serbia [2] Sector of Preventive Medicine, Military Medical Academy, Crnotravska 17, Belgrade 11000, Serbia.

Abstract

Sepsis is a principal cause of death in critical care units worldwide and consumes considerable healthcare resources. The aim of our study was to determine whether the early cytokine profile can discriminate between Gram-positive and Gram-negative bacteraemia (GPB and GNB, respectively) and to assess the prognostic value regarding outcome in critically ill patients with severe abdominal sepsis. The outcome measure was hospital mortality. Blood samples were obtained from 165 adult patients with confirmed severe abdominal sepsis. Levels of the proinflammatory mediators TNF-α, IL-8, IL-12 and IFN-γ and the anti-inflammatory mediators IL-1ra, IL-4, IL-10 and TGF-β1 were determined and correlated with the nature of the bacteria isolated from the blood culture and outcome. The cytokine profile in our study indicated that the TNF-α levels were 2-fold, IL-8 were 3.3-fold, IFN-γ were 13-fold, IL-1ra were 1.05-fold, IL-4 were 1.4-fold and IL-10 were 1.83-fold higher in the GNB group compared with the GPB group. The TNF-α levels were 4.7-fold, IL-8 were 4.6-fold, IL-1ra were 1.5-fold and IL-10 were 3.3-fold higher in the non-survivors compared with the survivors.

PMID:
26079127
PMCID:
PMC4468818
DOI:
10.1038/srep11355
[Indexed for MEDLINE]
Free PMC Article

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