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Korean J Urol. 2015 Jun;56(6):412-21. doi: 10.4111/kju.2015.56.6.412. Epub 2015 May 27.

Cell-based therapy for kidney disease.

Author information

1
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA. ; Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
2
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.

Abstract

The prevalence of renal disease continues to increase worldwide. When normal kidney is injured, the damaged renal tissue undergoes pathological and physiological events that lead to acute and chronic kidney diseases, which frequently progress to end stage renal failure. Current treatment of these renal pathologies includes dialysis, which is incapable of restoring full renal function. To address this issue, cell-based therapy has become a potential therapeutic option to treat renal pathologies. Recent development in cell therapy has demonstrated promising therapeutic outcomes, in terms of restoration of renal structure and function impaired by renal disease. This review focuses on the cell therapy approaches for the treatment of kidney diseases, including various cell sources used, as well recent advances made in preclinical and clinical studies.

KEYWORDS:

Acute kidney injury; Cell- and tissue-based therapy; Chronic kidney failure; Clinical trial; Evaluation studies

PMID:
26078837
PMCID:
PMC4462630
DOI:
10.4111/kju.2015.56.6.412
[Indexed for MEDLINE]
Free PMC Article

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