Format

Send to

Choose Destination
Oxid Med Cell Longev. 2015;2015:758358. doi: 10.1155/2015/758358. Epub 2015 May 11.

Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice.

Author information

1
Shanghai Key Laboratory of Bioactive Small Molecules and Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai 200032, China ; Department of Physiology, Hebei Medical University, Hebei 050017, China.
2
Shanghai Key Laboratory of Bioactive Small Molecules and Research Center on Aging and Medicine, Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai 200032, China.
3
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.

Abstract

AIMS:

To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts.

RESULTS:

Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction. H2S levels in plasma, heart tissues, and urine were significantly reduced in these mice as compared to those in controls. The expression of the H2S-generating enzymes, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-β-synthase levels were significantly increased.

CONCLUSION:

Our results suggest that this ageing diabetic mouse model developed diabetic cardiomyopathy and that H2S levels were reduced in the diabetic heart due to alterations in three H2S-producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.

PMID:
26078817
PMCID:
PMC4442299
DOI:
10.1155/2015/758358
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center