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J Appl Physiol (1985). 2015 Jun 15;118(12):1510-5. doi: 10.1152/japplphysiol.00023.2015. Epub 2015 Apr 2.

High dietary sodium reduces brachial artery flow-mediated dilation in humans with salt-sensitive and salt-resistant blood pressure.

Author information

1
Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and.
2
Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and Department of Behavioral Health and Nutrition, University of Delaware, Newark, Delaware.
3
Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware; and wbf@udel.edu.

Abstract

Recent studies demonstrate that high dietary sodium (HS) impairs endothelial function in those with salt-resistant (SR) blood pressure (BP). The effect of HS on endothelial function in those with salt-sensitive (SS) BP is not currently known. We hypothesized that HS would impair brachial artery flow-mediated dilation (FMD) to a greater extent in SS compared with SR adults. Ten SR (age 42 ± 5 yr, 5 men, 5 women) and 10 SS (age 39 ± 5 yr, 5 men, 5 women) healthy, normotensive participants were enrolled in a controlled feeding study consisting of a run-in diet followed by a 7-day low dietary sodium (LS) (20 mmol/day) and a 7-day HS (300 mmol/day) diet in random order. Brachial artery FMD and 24-h BP were assessed on the last day of each diet. SS BP was individually assessed and defined as a change in 24-h mean arterial pressure (MAP) of >5 mmHg between the LS and HS diets (ΔMAP: SR -0.6 ± 1.2, SS 7.7 ± 0.4 mmHg). Brachial artery FMD was lower in both SS and SR individuals during the HS diet (P < 0.001), and did not differ between groups (P > 0.05) (FMD: SR LS 10.6 ± 1.3%, SR HS 7.2 ± 1.5%, SS LS 12.5 ± 1.7%, SS HS 7.8 ± 1.4%). These data indicate that an HS diet impairs brachial artery FMD to a similar extent in adults with SS BP and SR BP.

KEYWORDS:

endothelial; flow-mediated dilation; vascular

PMID:
26078434
PMCID:
PMC4587630
DOI:
10.1152/japplphysiol.00023.2015
[Indexed for MEDLINE]
Free PMC Article

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