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Elife. 2015 Jun 16;4. doi: 10.7554/eLife.06694.

Dynamical feature extraction at the sensory periphery guides chemotaxis.

Author information

1
EMBL-CRG Systems Biology Program, Centre for Genomic Regulation, Barcelona, Spain.
2
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
3
Department of Mechanical Engineering and Materials Science, Yale University, New Haven, United States.

Abstract

Behavioral strategies employed for chemotaxis have been described across phyla, but the sensorimotor basis of this phenomenon has seldom been studied in naturalistic contexts. Here, we examine how signals experienced during free olfactory behaviors are processed by first-order olfactory sensory neurons (OSNs) of the Drosophila larva. We find that OSNs can act as differentiators that transiently normalize stimulus intensity-a property potentially derived from a combination of integral feedback and feed-forward regulation of olfactory transduction. In olfactory virtual reality experiments, we report that high activity levels of the OSN suppress turning, whereas low activity levels facilitate turning. Using a generalized linear model, we explain how peripheral encoding of olfactory stimuli modulates the probability of switching from a run to a turn. Our work clarifies the link between computations carried out at the sensory periphery and action selection underlying navigation in odor gradients.

KEYWORDS:

D. melanogaster; chemotaxis; computational biology; computational modeling; electrophysiology; neuroscience; olfaction; optogenetics; sensorimotor control; systems biology

Comment in

PMID:
26077825
PMCID:
PMC4468351
DOI:
10.7554/eLife.06694
[Indexed for MEDLINE]
Free PMC Article

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