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Clin Respir J. 2017 May;11(3):337-345. doi: 10.1111/crj.12341. Epub 2015 Jul 7.

Serum Krebs von den Lungen-6 level as a diagnostic biomarker for interstitial lung disease in Chinese patients.

Author information

1
Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
2
Department of Respiratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
3
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Abstract

OBJECTIVES:

The purpose of this study was to determine the diagnostic and prognostic values of serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs).

METHODS:

A total of 1084 subjects including 373 cases of ILDs, 584 cases of non-ILD pulmonary diseases, and 127 healthy individuals were recruited from three clinical centers in China between January 2011 and December 2013. A total of 106 patients undergoing treatments for ILDs in Shanghai Pulmonary Hospital between January 2011 and December 2013 were enrolled. Baseline and posttreatment serum KL-6 levels were determined.

RESULTS:

Serum KL-6 levels in patients with ILDs were significantly higher than those in patients with non-ILD pulmonary diseases or in healthy individuals (1492.09 ± 2230.08 U/mL vs 258.67 ± 268.73 U/mL or 178.73 ± 71.17 U/mL, all P < 0.05). At the cut-off value of 500 U/mL, the sensitivity and specificity of serum KL-6 as a diagnostic marker for ILDs was 77.75% and 94.51%, respectively. The Kappa value was 0.743 (P < 0.001). The area below the receiver operating characteristic curve was 0.922 with a 95% Confidence interval of 0.904-0.941 (P < 0.001). The posttreatment serum KL-6 levels significantly reduced in patients with improved ILDs, whereas markedly increased in patients with exacerbated ILDs (All P < 0.05).

CONCLUSIONS:

Serum KL-6 levels might be a promising diagnostic biomarker for ILDs in Chinese patients. The prognostic value of serum KL-6 levels for ILDs remains to be verified by large-scaled studies.

KEYWORDS:

KL-6; biomarker; diagnosis; interstitial lung disease; prognosis

PMID:
26077281
DOI:
10.1111/crj.12341
[Indexed for MEDLINE]

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