Format

Send to

Choose Destination
J Cell Commun Signal. 2015 Sep;9(3):291-6. doi: 10.1007/s12079-015-0297-3. Epub 2015 Jun 16.

A knowledgebase resource for interleukin-17 family mediated signaling.

Author information

1
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. jyoti@ibioinformatics.org.
2
Manipal University, Madhav Nagar, Manipal, 576104, India. jyoti@ibioinformatics.org.
3
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. lavanya@ibioinformatics.org.
4
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. keshavadatta@ibioinformatics.org.
5
School of Biotechnology, KIIT University, Bhubaneswar, 751024, India. keshavadatta@ibioinformatics.org.
6
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. nandini.jhmi@gmail.com.
7
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. aafaque@ibioinformatics.org.
8
School of Biotechnology, KIIT University, Bhubaneswar, 751024, India. aafaque@ibioinformatics.org.
9
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. apeksha@ibioinformatics.org.
10
Bioinformatics Centre, School of Life Sciences, Pondicherry University, Puducherry, 605014, India. apeksha@ibioinformatics.org.
11
Manipal University, Madhav Nagar, Manipal, 576104, India. asksinghal@gmail.com.
12
Kasturba Medical College, Mangalore, 575001, India. asksinghal@gmail.com.
13
McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA. get.derese@gmail.com.
14
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. rajrrnbt@gmail.com.
15
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Poojappura, Kerala, 695014, India. rajrrnbt@gmail.com.
16
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. aditi@ibioinformatics.org.
17
Manipal University, Madhav Nagar, Manipal, 576104, India. aditi@ibioinformatics.org.
18
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. harsha@ibioinformatics.org.
19
School of Biotechnology, KIIT University, Bhubaneswar, 751024, India. harsha@ibioinformatics.org.
20
Institute of Bioinformatics, International Technology Park, Bangalore, 560066, India. keshav@ibioinformatics.org.
21
Manipal University, Madhav Nagar, Manipal, 576104, India. keshav@ibioinformatics.org.
22
Command Hospital (Air Force), Bangalore, 560007, India. shankar@ibioinformatics.org.
23
McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA. pandey@jhmi.edu.

Abstract

Interleukin-17 (IL-17) belongs to a relatively new family of cytokines that has garnered attention as the signature cytokine of Th17 cells. This cytokine family consists of 6 ligands, which bind to 5 receptor subtypes and induce downstream signaling. Although the receptors are ubiquitously expressed, cellular responses to ligands vary across tissues. The cytokine family is associated with various autoimmune disorders including rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma and psoriasis in addition to being implicated in the pathogenesis of cancer. In addition, this family plays a role in host defense against bacterial and fungal infections. The signaling mechanisms of the IL-17 family of proinflammatory cytokines are not well explored. In this study, we present a resource of literature-annotated reactions induced by IL-17. The reactions are catalogued under 5 categories, namely; molecular association, catalysis, transport, activation/inhibition and gene regulation. A total of 93 molecules and 122 reactions have been annotated. The IL-17 pathway is freely available through NetPath, a resource of signal transduction pathways previously developed by our group.

KEYWORDS:

Activation; Differential expression; Inhibition; NetPath; Post-translational modifications; Protein-protein interaction; Translocation

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center