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J Clin Pathol. 2015 Oct;68(10):839-43. doi: 10.1136/jclinpath-2015-203012. Epub 2015 Jun 15.

Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer.

Author information

1
Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre, University of Toronto, Toronto, Canada.
2
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
3
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.
4
Medical Oncology Department and Translational Research Unit, Albacete University Hospital, Albacete, Spain.
5
Sector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Abstract

BACKGROUND:

The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.

METHODS:

The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.

RESULTS:

Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1-53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=-0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.

CONCLUSIONS:

AR is associated with lower RS, but not with Ki-67.

KEYWORDS:

BREAST CANCER; HORMONE; MOLECULAR ONCOLOGY

PMID:
26076967
DOI:
10.1136/jclinpath-2015-203012
[Indexed for MEDLINE]

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