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Br J Pharmacol. 2015 Sep;172(17):4254-76. doi: 10.1111/bph.13222. Epub 2015 Jul 28.

Ketamine and phencyclidine: the good, the bad and the unexpected.

Author information

1
Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, UK.

Abstract

The history of ketamine and phencyclidine from their development as potential clinical anaesthetics through drugs of abuse and animal models of schizophrenia to potential rapidly acting antidepressants is reviewed. The discovery in 1983 of the NMDA receptor antagonist property of ketamine and phencyclidine was a key step to understanding their pharmacology, including their psychotomimetic effects in man. This review describes the historical context and the course of that discovery and its expansion into other hallucinatory drugs. The relevance of these findings to modern hypotheses of schizophrenia and the implications for drug discovery are reviewed. The findings of the rapidly acting antidepressant effects of ketamine in man are discussed in relation to other glutamatergic mechanisms.

PMID:
26075331
PMCID:
PMC4556466
DOI:
10.1111/bph.13222
[Indexed for MEDLINE]
Free PMC Article

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