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Front Oncol. 2015 May 26;5:108. doi: 10.3389/fonc.2015.00108. eCollection 2015.

The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis.

Author information

1
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL , USA ; Department of Cell Biology, University of Miami Miller School of Medicine , Miami, FL , USA.
2
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL , USA ; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine , Miami, FL , USA.
3
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL , USA ; Department of Medicine, University of Miami Miller School of Medicine , Miami, FL , USA.

Abstract

Histone, and non-histone, protein acetylation plays an important role in a variety of cellular events, including the normal and abnormal development of blood cells, by changing the epigenetic status of chromatin and regulating non-histone protein function. Histone acetyltransferases (HATs), which are the enzymes responsible for histone and non-histone protein acetylation, contain p300/CBP, MYST, and GNAT family members. HATs are not only protein modifiers and epigenetic factors but also critical regulators of cell development and carcinogenesis. Here, we will review the function of HATs such as p300/CBP, Tip60, MOZ/MORF, and GCN5/PCAF in normal hematopoiesis and the pathogenesis of hematological malignancies. The inhibitors that have been developed to target HATs will also be reviewed here. Understanding the roles of HATs in normal/malignant hematopoiesis will provide the potential therapeutic targets for the hematological malignancies.

KEYWORDS:

hematological malignancies; hematopoiesis; hematopoietic stem cells; histone acetyltransferases; transcriptional regulation

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