Format

Send to

Choose Destination
Front Neurosci. 2015 May 19;9:177. doi: 10.3389/fnins.2015.00177. eCollection 2015.

Secondary psychosis induced by metabolic disorders.

Author information

1
Psychology Laboratory of Pays de la Loire (LPPL), U2PEA Department of Child and Adolescent Psychiatry, Centre Hospitalier Universitaire de Nantes, University of Angers Nantes, France.
2
Psychology Laboratory of Pays de la Loire (LPPL), U2PEA Department of Child and Adolescent Psychiatry, Centre Hospitalier Universitaire de Nantes, University of Angers Nantes, France ; Grupo de Investigación en Neurociencias NeURos, Universidad del Rosario Bogota, Colombia.
3
Department of Child an Adolescent Psychiatry, Centre Hospitalier Guillaume Regnier, University of Rennes Rennes, France.
4
Neuropsychiatry Unit, Royal Melbourne Hospital Melbourne, VIC, Australia ; Melbourne Neuropsychiatry Centre, University of Melbourne Melbourne, VIC, Australia.

Abstract

Metabolic disorders are not well-recognized by psychiatrists as a possible source of secondary psychoses. Inborn errors of metabolism (IEMs) are not frequent. Although their prompt diagnosis may lead to suitable treatments. IEMs are well-known to pediatricians, in particular for their most serious forms, having an early expression most of the time. Recent years discoveries have unveiled later expression forms, and sometimes very discreet first physical signs. There is a growing body of evidence that supports the hypothesis that IEMs can manifest as atypical psychiatric symptoms, even in the absence of clear neurological symptoms. In the present review, we propose a detailed overview at schizophrenia-like and autism-like symptoms that can lead practitioners to bear in mind an IEM. Other psychiatric manifestations are also found, as behavioral, cognitive, learning, and mood disorders. However, they are less frequent. Ensuring an accurate IEM diagnosis, in front of these psychiatric symptoms should be a priority, in order to grant suitable and valuable treatment for these pathologies.

KEYWORDS:

IEMs; atypicalness; homocysteine; neurometabolic disorders; organic psychosis; schizophrenia-like; urea

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center