Format

Send to

Choose Destination
Adv Immunol. 2015;127:145-201. doi: 10.1016/bs.ai.2015.03.003. Epub 2015 Apr 25.

Activation and Function of iNKT and MAIT Cells.

Author information

1
La Jolla Institute for Allergy & Immunology, La Jolla, California, USA.
2
La Jolla Institute for Allergy & Immunology, La Jolla, California, USA. Electronic address: mitch@lji.org.

Abstract

Over the last two decades, it has been established that peptides are not the only antigens recognized by T lymphocytes. Here, we review information on two T lymphocyte populations that recognize nonpeptide antigens: invariant natural killer T cells (iNKT cells), which respond to glycolipids, and mucosal associated invariant T cells (MAIT cells), which recognize microbial metabolites. These two populations have a number of striking properties that distinguish them from the majority of T cells. First, their cognate antigens are presented by nonclassical class I antigen-presenting molecules; CD1d for iNKT cells and MR1 for MAIT cells. Second, these T lymphocyte populations have a highly restricted diversity of their T cell antigen receptor α chains. Third, these cells respond rapidly to antigen or cytokine stimulation by producing copious amounts of cytokines, such as IFNγ, which normally are only made by highly differentiated effector T lymphocytes. Because of their response characteristics, iNKT and MAIT cells act at the interface of innate and adaptive immunity, participating in both types of responses. In this review, we will compare these two subsets of innate-like T cells, with an emphasis on the various ways that lead to their activation and their participation in antimicrobial responses.

KEYWORDS:

Glycolipid antigen; Memory T cells; Microbial infection; T cell antigen receptor; Vitamin B metabolite; iNKT and MAIT

PMID:
26073984
DOI:
10.1016/bs.ai.2015.03.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center