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Nat Commun. 2015 Jun 15;6:7292. doi: 10.1038/ncomms8292.

Physical principles of membrane remodelling during cell mechanoadaptation.

Author information

1
Institute for Bioengineering of Catalonia (IBEC), Barcelona 08028, Spain.
2
Department of Physiological Sciences I, University of Barcelona, Barcelona 08036, Spain.
3
National Centre for Biological Sciences (TIFR), Bangalore 560065, India.
4
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.
5
LaCàN, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona 08034, Spain.
6
Ciber Enfermedades Respiratorias, Madrid 28029, Spain.
7
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.
8
Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.

Abstract

Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes.

PMID:
26073653
PMCID:
PMC4490354
DOI:
10.1038/ncomms8292
[Indexed for MEDLINE]
Free PMC Article

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