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Magn Reson Med. 2016 May;75(5):2072-7. doi: 10.1002/mrm.25791. Epub 2015 Jun 15.

Quiescent interval low angle shot magnetic resonance angiography of the extracranial carotid arteries.

Author information

1
Department of Radiology, NorthShore University HealthSystem, Evanston, Illinois, USA.
2
University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
3
Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
4
Siemens Healthcare, Chicago, Illinois, USA.

Abstract

PURPOSE:

To test the feasibility of a quiescent interval low-angle shot (QLASH) sequence for nonenhanced MR angiography (MRA) of the extracranial carotid arteries at 3 T.

METHODS:

The extracranial carotid arteries were imaged using QLASH MRA in healthy volunteers and patients with carotid arterial disease. The impact of three gating strategies (electrocardiographic-gated, pulse-gated, ungated) was evaluated. Image quality comparisons were made with respect to two-dimensional (2D) time of flight (TOF) MRA in volunteers and patients and contrast-enhanced MRA (CEMRA) in patients. Stenoses in patients were graded.

RESULTS:

QLASH MRA displayed the entire extent of the extracranial carotid arteries from their origins to the skull base. Electrocardiographic-gated QLASH MRA provided better image quality than pulse-gated and ungated implementations (P < 0.05) as well as 2D TOF MRA (P < 0.05). For grading of disease, QLASH MRA showed almost perfect agreement with CEMRA (Cohen's kappa = 0.86, P < 0.001) in a small cohort of patients with carotid arterial stenosis.

CONCLUSION:

QLASH MRA allows for evaluation of the entire extent of the extracranial carotid arteries with an average scan time of less than 6 min and better image quality than 2D TOF. Initial clinical results in this pilot study suggest that QLASH has potential utility as a nonenhanced alternative to CEMRA.

KEYWORDS:

MRA; QISS; QLASH; carotid; flow artifact; time of flight

PMID:
26072706
DOI:
10.1002/mrm.25791
[Indexed for MEDLINE]

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