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Trends Genet. 2015 Sep;31(9):509-15. doi: 10.1016/j.tig.2015.05.005. Epub 2015 Jun 10.

From milliseconds to lifetimes: tracking the dynamic behavior of transcription factors in gene networks.

Author information

1
Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003, USA.
2
Center for Genomics and Systems Biology, Department of Biology, New York University, New York, NY 10003, USA. Electronic address: gloria.coruzzi@nyu.edu.

Abstract

Modeling dynamic gene regulatory networks (GRNs) is a new frontier in systems biology. It has special implications for plants, whose survival requires rapid deployment of GRNs in response to environmental changes. However, capturing and dissecting transient interactions of transcription factors (TFs) and their targets in GRNs remains a considerable experimental challenge. Here we review recent progress in understanding GRNs as a function of time and discuss the relevance of these findings in plants to studies in other eukaryotes. We cover progress in profiling and modeling time-course transcriptome changes across plant species and the insights they have provided into the regulatory mechanisms underlying these temporal transcriptional responses, with a focus on the dynamic behavior of TFs. Lastly, we review state-of-the-art techniques to monitor the single-molecule dynamics of TFs in vivo. Together, these advances have helped develop new models for dynamic transcriptional control with relevance across eukaryotes.

KEYWORDS:

gene regulatory networks; transcription dynamics; transcription factors

PMID:
26072453
PMCID:
PMC4558309
DOI:
10.1016/j.tig.2015.05.005
[Indexed for MEDLINE]
Free PMC Article

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