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Trends Immunol. 2015 Jul;36(7):428-35. doi: 10.1016/j.it.2015.05.003. Epub 2015 Jun 10.

Emerging concepts in tissue-resident T cells: lessons from humans.

Author information

1
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
2
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: df2396@cumc.columbia.edu.

Abstract

Intensified efforts to promote protective T cell-based immunity in vaccines and immunotherapies have created a compelling need to expand our understanding of human T cell function and maintenance beyond its characterization in peripheral blood. Mouse studies of T cell immunity show that, in response to infection, T cells migrate to diverse sites and persist as tissue-resident memory T cells (TRM), which mediate rapid in situ protection on antigen recall. Here we discuss new approaches to probe human T cell immunity, including novel sampling, that indicate a broad distribution and high frequency of human TRM in multiple sites. These newer findings further implicate anatomic compartmentalization as a generalized mechanism for long-term maintenance of human T cells throughout life.

KEYWORDS:

immune homeostasis; immune memory; mucosal immunity; naïve T cells; peripheral blood

PMID:
26072286
PMCID:
PMC4491028
DOI:
10.1016/j.it.2015.05.003
[Indexed for MEDLINE]
Free PMC Article

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