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Prog Brain Res. 2015;219:187-216. doi: 10.1016/bs.pbr.2015.03.002. Epub 2015 May 16.

Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions.

Author information

1
School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK. Electronic address: emilie.werlen@bristol.ac.uk.
2
School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK.

Abstract

Salient events activate the midbrain dopaminergic system and have important impacts on various aspects of mnemonic function, including the stability of hippocampus-dependent memories. Dopamine is also central to modulation of neocortical memory processing, particularly during prefrontal cortex-dependent working memory. Here, we review the current state of the circuitry and physiology underlying dopamine's actions, suggesting that--alongside local effects within hippocampus and prefrontal cortex--dopamine released from the midbrain ventral tegmental area is well positioned to dynamically tune interactions between limbic-cortical circuits through modulation of rhythmic network activity.

KEYWORDS:

Dopamine; Hippocampus; Learning and memory; Prefrontal cortex; Theta coherence

PMID:
26072240
DOI:
10.1016/bs.pbr.2015.03.002
[Indexed for MEDLINE]

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