Format

Send to

Choose Destination
Acta Neurol Belg. 2016 Mar;116(1):43-6. doi: 10.1007/s13760-015-0496-y. Epub 2015 Jun 14.

Serostatus of Epstein-Barr virus in Iranian MS patients.

Author information

1
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Hemmat Highway, Tehran, Iran.
2
Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran. hamid.6300@gmail.com.
3
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
4
Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
5
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. keyvanlab@yahoo.com.

Abstract

Multiple sclerosis (MS) is a common, complex disorder. Associations of MS with Epstein-Barr virus (EBV) infection in Caucasian populations are well documented. However, in the Iranian population, previous studies have been conflicting. Sixty patients with MS and 50 healthy controls were tested for anti-EBV antibodies using chemiluminescent assays. All MS patients to be seropositive for EBV as compared to 82 % of controls (p = 0.0006). A strong, significant association of MS with EBV infection was documented, similar to studies in first world populations. Future studies should investigate the temporal sequence of infection to try to understand the cause of the recent increase in MS risk in Iran.

KEYWORDS:

Environmental factors; Epstein–Barr virus; Immunoglobulin; Infection; Multiple sclerosis; Serology

PMID:
26071762
DOI:
10.1007/s13760-015-0496-y
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center