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Trends Pharmacol Sci. 2015 Sep;36(9):568-78. doi: 10.1016/j.tips.2015.05.007. Epub 2015 Jun 9.

The role of H2S bioavailability in endothelial dysfunction.

Author information

1
Department of Biology, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON P3E 2C6, Canada. Electronic address: rui.wang@laurentian.ca.
2
Department of Anesthesiology, The University of Texas Medical Branch at Galveston, 601 Harborside Drive, Galveston, TX 77555, USA.
3
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
4
Aston Medical Research Institute, Aston Medical School, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
5
University of Exeter Medical School, St. Luke's Campus, Magdalen Road, Exeter EX1 2LU, UK.
6
Faculty of Pharmacy, University of Athens, Zografou Campus, Athens, 15771, Greece; George P. Livanos and Marianthi Simou Laboratories, First Department of Pulmonary and Critical Care Medicine, Evangelismos Hospital, Faculty of Medicine, University of Athens, Athens, 10675, Greece.

Abstract

Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.

KEYWORDS:

cystathionine gamma-lyase; endothelium-derived hyperpolarizing factor; gasotransmitters; heme oxygenase-1; hydrogen sulfide; nitric oxide

PMID:
26071118
PMCID:
PMC4562801
DOI:
10.1016/j.tips.2015.05.007
[Indexed for MEDLINE]
Free PMC Article

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