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Rheumatology (Oxford). 2015 Sep;54(9):1541-8. doi: 10.1093/rheumatology/kev223. Epub 2015 Jun 11.

Renal involvement in primary Sjögren's syndrome.

Author information

1
UCL Centre for Nephrology, UCL Medical School, Rowland Hill Street and.
2
Department of Rheumatology, University College London Hospital, London, UK.
3
UCL Centre for Nephrology, UCL Medical School, Rowland Hill Street and stephen.walsh@ucl.ac.uk.

Abstract

SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.

KEYWORDS:

B cells; Fanconi syndrome; Sjögren’s syndrome; Th17 cells; autoantibodies; autoimmune epithelialitis; distal renal tubular acidosis; hypocomplementaemia; tubulointerstitial nephritis; vasculitis

PMID:
26070939
DOI:
10.1093/rheumatology/kev223
[Indexed for MEDLINE]

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