Send to

Choose Destination
Psychiatry Res. 2015 Oct 30;229(3):1031-7. doi: 10.1016/j.psychres.2015.05.021. Epub 2015 May 29.

Increased homocysteine levels correlate with the communication deficit in children with autism spectrum disorder.

Author information

Area of Mental Health and Psychiatry, Hospital of Sagunto, Sagunto, Valencia, Spain.
Children׳s Mental Health Centre, Hospital Arnau de Villanova, Valencia, Spain.
Diagnostic Centre Calderón, Castellón, Spain.
Diagnostic Centre CEDIN, Valencia, Spain.
Department of Nursing, University of Valencia, c/Jaume Roig s/n, 46010 Valencia, Spain. Electronic address:


The clinical significance of high levels of homocysteine in autism spectrum disorder (ASD) is unknown. An experimental study was conducted in order to evaluate the concentration of homocysteine in children with ASD and typically developing children and to analyse any relationships with the severity of core symptoms of ASD and other clinical features (drugs, co-morbidities, gender, age, diet). Core symptoms of autism were evaluated by DSM-IV criteria. Homocysteine, glutathione, methionine, 3-nitrotyrosine were measured in urine. The increase in homocysteine concentration was significantly and directly correlated with the severity of the deficit in communication skills, but was unrelated to deficit in socialisation or repetitive/restricted behaviour. Urinary homocysteine concentration may be a possible biomarker for communication deficits in ASD and a potential diagnostic tool useful to evaluate new treatment options since no treatment for core symptoms of ASD are available.


Autism spectrum disorder; Biomarker; Core symptoms; Homocysteine; Language development; Metabolism

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center