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J Affect Disord. 2015 Sep 15;184:60-6. doi: 10.1016/j.jad.2015.05.041. Epub 2015 May 30.

Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients.

Author information

1
Pôle de psychiatrie, Hôpital Sainte Marguerite, Assistance Publique Hôpitaux de Marseille, France; Aix-Marseille Université, CNRS, CRN2M UMR 7286, 13344 cedex 15, Marseille, France; Fondation FondaMental, Créteil, France. Electronic address: raoul.belzeaux@ap-hm.fr.
2
EA 3279-Self-perceived Health Assessment Research Unit, School of Medicine, Timone University, Marseille, France.
3
Aix-Marseille Université, CNRS, INT UMR 7289, 13385 cedex 15, Marseille, France.
4
Pôle de psychiatrie, Hôpital Sainte Marguerite, Assistance Publique Hôpitaux de Marseille, France; Fondation FondaMental, Créteil, France.
5
Fondation FondaMental, Créteil, France; Service de psychiatrie, Centre hospitalier Princesse-Grace, Avenue Pasteur, Monaco.
6
Fondation FondaMental, Créteil, France; AP-HP, GH Saint-Louis-Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France.
7
Fondation FondaMental, Créteil, France; Clinique Universitaire de Psychiatrie, CHU de Grenoble, Grenoble, France.
8
Fondation FondaMental, Créteil, France; Département d'Urgence et Post Urgence Psychiatrique, CHRU Montpellier, INSERM U1061, Université Montpellier 1, Montpellier, France.
9
Fondation FondaMental, Créteil, France; Inserm, U955, Equipe de psychiatrie génétique et Université Paris Est, Faculté de médecine et AP-HP, Hôpitaux Universitaires Henri Mondor, Pôle de psychiatrie, Créteil 94000, France.
10
Fondation FondaMental, Créteil, France; Hôpital Charles Perrens, Centre Expert Trouble Bipolaire, Service de psychiatrie adulte, Pôle 3-4-7, Bordeaux, France.
11
Fondation FondaMental, Créteil, France; Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy, France; Université de Lorraine, France.
12
Fondation FondaMental, Créteil, France; Université de Versailles Saint-Quentin, Centre Hospitalier de Versailles, Service de Psychiatrie Adulte, Le Chesnay, France.
13
Pôle de psychiatrie, Hôpital Sainte Marguerite, Assistance Publique Hôpitaux de Marseille, France; Fondation FondaMental, Créteil, France; EA 3279-Self-perceived Health Assessment Research Unit, School of Medicine, Timone University, Marseille, France.

Abstract

BACKGROUND:

Adherence to medication is a major issue in bipolar disorder. Non-planning impulsivity, defined as a lack of future orientation, has been demonstrated to be the main impulsivity domain altered during euthymia in bipolar disorder patients. It was associated with comorbidities.

METHODS:

To investigate relationship between adherence to medication and non-planning impulsivity, we included 260 euthymic bipolar patients. Adherence to medication was evaluated by Medication Adherence Rating Scale and non-planning impulsivity by Barrat Impulsiveness Scale. Univariate analyses and linear regression were used. We conducted also a path analysis to examine whether non-planning impulsivity had direct or indirect effect on adherence, mediated by comorbidities.

RESULTS:

Adherence to medication was correlated with non-planning impulsivity, even after controlling for potential confounding factors in linear regression analysis (Beta standardized coefficient = 0.156; p = 0.015). Path analysis demonstrated only a direct effect of non-planning impulsivity on adherence to medication, and none indirect effect via substance use disorders and anxiety disorders.

LIMITATIONS:

Our study is limited by its cross-sectional design and adherence to medication was assessed only by self-questionnaire.

CONCLUSIONS:

Higher non-planning impulsivity is associated with low medication adherence, without an indirect effect via comorbidities.

KEYWORDS:

Anxiety disorders; Impulsivity; Mood disorders; Substance Use Disorders

PMID:
26070047
DOI:
10.1016/j.jad.2015.05.041
[Indexed for MEDLINE]

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