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Cartilage. 2010 Jan;1(1):65-8. doi: 10.1177/1947603509360044.

Autologous Matrix-Induced Chondrogenesis (AMIC): Combining Microfracturing and a Collagen I/III Matrix for Articular Cartilage Resurfacing.

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Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland.
Department of Orthopaedic Surgery, University of Luebeck, Luebeck, Germany.


Options for the treatment of cartilage defects include chondral resurfacing with abrasion, debridement, autologous chondrocyte transplantation (ACT), matrix-induced chondrocyte transplantation (MACI), or osteochondral autologous transplantation (OATS). This article describes the new method of autologous matrix-induced chondrogenesis (AMIC), a 1-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane by a partially autologous fibrin glue. Indications and contraindications are provided; a technical note is given. This method is primarily applied in osteochondral lesions of the knee and ankle joints; other joints may qualify.


AMIC; autologous cartilage repair; microfracturing

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