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Cartilage. 2010 Jan;1(1):65-8. doi: 10.1177/1947603509360044.

Autologous Matrix-Induced Chondrogenesis (AMIC): Combining Microfracturing and a Collagen I/III Matrix for Articular Cartilage Resurfacing.

Author information

1
Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland.
2
Department of Orthopaedic Surgery, University of Luebeck, Luebeck, Germany.

Abstract

Options for the treatment of cartilage defects include chondral resurfacing with abrasion, debridement, autologous chondrocyte transplantation (ACT), matrix-induced chondrocyte transplantation (MACI), or osteochondral autologous transplantation (OATS). This article describes the new method of autologous matrix-induced chondrogenesis (AMIC), a 1-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane by a partially autologous fibrin glue. Indications and contraindications are provided; a technical note is given. This method is primarily applied in osteochondral lesions of the knee and ankle joints; other joints may qualify.

KEYWORDS:

AMIC; autologous cartilage repair; microfracturing

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