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Int J Physiol Pathophysiol Pharmacol. 2015 Mar 20;7(1):1-13. eCollection 2015.

Coenzyme Q10 protects against acute consequences of experimental myocardial infarction in rats.

Author information

1
Department of Applied Medical Sciences, College of Health Sciences PAAET, Kuwait.
2
Department of Physiology, College of Medicine, King Khalid University Kingdom of Saudi Arabia ; Department of Biology, IK Barber School of Arts and Sciences UBC-Okanagan, Kelowna, BC, Canada.
3
Department of Biology, IK Barber School of Arts and Sciences UBC-Okanagan, Kelowna, BC, Canada.
4
Department of Physiology, College of Medicine, King Khalid University Kingdom of Saudi Arabia.
5
Department of internal medicine, Cardiology section, College of Medicine, King Khalid University Kingdom of Saudi Arabia.
6
Division of Physiology, Department of Basic Medical Sciences, Faculty of Medicine, King Saud bin Abdul Aziz University for Health Sciences King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia.

Abstract

AIM:

Myocardial infarction (MI) due to sudden occlusion of a major coronary artery leads to a complex series of events that result in left ventricle (LV) impairment eventual heart failure. Therapeutic options are limited to reverse such trends post MI. The aim of this study was to compare the acute cardioprotective effects of the antioxidants, resveratrol (RES) and coenzyme Q10 (CoQ10), either individually or in combination, on infracts size, LV hemodynamics, inflammation and oxidative stress markers in rats with experimentally induced MI.

METHODS:

Male Wistar rats were randomly divided into six groups: control without surgery, sham without occlusion, MI without antioxidants, RES pre-treated then MI (20 mg/kg, orally), CoQ10 then MI (20 mg/kg, intramuscular.), and combined RES and CoQ10 then MI with (each group n = 10). Pretreatment commenced 7 days prior to the permanent occlusion of the left anterior descending (LAD) coronary artery. Infarct area, hemodynamics, inflammation and oxidative stress markers were assessed 24 hours post-MI.

RESULTS:

Compared to RES alone, CoQ10 pre-administration either by itself or in combination with RES, significantly reduced LV infarct area (57%), and normalized LV hemodynamic parameters like LVEDP (100%), LVSP (95.4%), LV +dp/dt and -dp/dt (102 and 73.1%, respectively). CoQ10 also decreased serum levels of brain natriuretic peptide (70%), and various circulating inflammatory markers like TNF-α (83.2%) and IL-6 (83.2%). Regarding oxidative stress, TBARS scores were lowered with a concurrent increase in both superoxide dismutase and glutathione peroxidase activities with CoQ10 alone or in combination with RES.

CONCLUSION:

Coenzyme Q10 protects against the acute sequelae of myocardial infarction. It profoundly reduced infarct area, inflammation and oxidative stress while normalizing LV hemodynamics post MI.

KEYWORDS:

Myocardial infarction; apoptosis; coenzyme Q10; hemodynamics; oxidative stress; resveratrol

PMID:
26069524
PMCID:
PMC4446384

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