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Thorax. 2015 Oct;70(10):998-1000. doi: 10.1136/thoraxjnl-2015-207246. Epub 2015 Jun 11.

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.

Author information

1
Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada.
2
McMaster University, Hamilton, Canada.
3
University of Manitoba, Winnipeg, Canada.
4
University of Alberta, Edmonton, Canada.
5
University of British Columbia, Vancouver, Canada.
6
Environment Canada, Toronto, Canada.
7
University of Toronto, Toronto, Canada.
8
Northwestern University, Chicago, USA.
9
Simon Fraser University, Vancouver, Canada.

Abstract

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases.

KEYWORDS:

Allergic lung disease; Asthma; Asthma Epidemiology; Asthma Genetics; Asthma Mechanisms; Paediatric asthma; Respiratory Measurement; Viral infection

PMID:
26069286
DOI:
10.1136/thoraxjnl-2015-207246
[Indexed for MEDLINE]

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