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Eur J Dermatol. 2015 Sep-Oct;25(5):384-91. doi: 10.1684/ejd.2015.2544.

Retinoid treatment of skin diseases.

Author information

1
Department of Dermatology, SLK Hospital Heilbronn, Am Gesundbrunnen 20 -26, 74078 Heilbronn, Germany.
2
Department of Dermatology and Allergology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.
3
Department of Dermatology, SLK Hospital Heilbronn, Am Gesundbrunnen 20 -26, 74078 Heilbronn, Germany, Department of Dermatology and Allergology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany.

Abstract

Retinoids (vitamin A and its metabolites) are potent natural regulators of cellular activities, including cell growth and differentiation, and they mediate many essential regulatory functions, especially in the skin. Biologically active retinoids exert their effects by binding to nuclear retinoic acid receptors and retinoid-X-receptors. The group of pharmacologically used retinoids include naturally occurring and chemically synthesised vitamin A derivatives. Due to their influence on keratinocyte proliferation, epidermal differentiation and keratinisation, retinoids are commonly used in the field of dermatopharmacology. For safe administration of retinoids, in-depth information about adverse effects and comprehensive information of the patient are important. This article gives an overview on the effects, use, and side-effects of topical and systemic retinoids in dermatology.

KEYWORDS:

dermatopharmacology; retinoid therapy; retinoids; vitamin A derivatives

PMID:
26069148
DOI:
10.1684/ejd.2015.2544
[Indexed for MEDLINE]

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