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Trends Endocrinol Metab. 2015 Jul;26(7):384-94. doi: 10.1016/j.tem.2015.05.002. Epub 2015 Jun 9.

Epidemiology of air pollution and diabetes.

Author information

1
Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany. Electronic address: elisabeth.thiering@helmholtz-muenchen.de.
2
Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany.

Abstract

Air pollution affects a large proportion of the global population. Air pollutants are hypothesized to exert their effects via impaired endothelial function, elevated systemic inflammation, mitochondrial dysfunction, and oxidative stress, all of which are hallmarks of type 2 diabetes (T2D). Here we review epidemiological studies aimed at answering whether diabetes patients are more vulnerable to ambient (outdoor) air pollution exposure and whether air pollution is associated with diabetes development or other predisposing conditions for T2D. Current evidence suggests an association between air pollution exposure and T2D, but more critical analysis is warranted. Understanding the associations between air pollution exposure and the development of T2D is critical in our efforts to control sources of air pollution and their impact on the disease.

KEYWORDS:

air pollution; gestational diabetes; mortality; type 2 diabetes

PMID:
26068457
DOI:
10.1016/j.tem.2015.05.002
[Indexed for MEDLINE]
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