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J Cell Commun Signal. 2015 Sep;9(3):279-80. doi: 10.1007/s12079-015-0298-2. Epub 2015 Jun 12.

How do benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma favor tumor progression?

Author information

1
Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira 13, Ponte Preta, 13045-755, Campinas, Brazil.
2
Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira 13, Ponte Preta, 13045-755, Campinas, Brazil. vcaraujo@usp.br.

Abstract

In this brief commentary, we have shown how the benign myoepithelial cells from in situ areas of carcinoma ex-pleomorphic adenoma from salivary gland can favor tumor progression, not only dying by autophagy/senescence phenomena, disrupting the physical barrier, but also providing fuel for tumor progression.

KEYWORDS:

Carcinoma ex-pleomorphic adenoma; In situ condition; Myoepithelial cells

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