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J Asian Nat Prod Res. 2015;17(10):959-66. doi: 10.1080/10286020.2015.1048685. Epub 2015 Jun 12.

Norlignans from Pouzolzia zeylanica var. microphylla and their nitric oxide inhibitory activity.

Author information

1
a School of Traditional Chinese Medicine, Guangdong Pharmaceutical University , Guangzhou 510006 , China.

Abstract

Five new compounds, pouzolignan F [4-hydroxy-3-(3,5-dihydroxyphenyl)-2-[bis(4-hydroxy-3-methoxyphenyl)methyl]butyl acetate] (1), pouzolignan G [4-hydroxy-3-(3,5-dihydroxyphenyl)-2-[(4-hydroxy-3,5-dimethoxyphenyl)(4-hydroxy-3-methoxyphenyl)methyl]butyl acetate] (2), pouzolignan H [1,4-dihydroxy-3-(3,5-dihydroxyphenyl)-2-[bis(4-hydroxy-3-methoxyphenyl)methyl]butane] (3), pouzolignan I [1,4-dihydroxy-3-(3,5-dihydroxyphenyl)-2-[(4-hydroxy-3,5-dime thoxyphenyl)-(4-hydroxy-3-methoxyphenyl)methyl]butane] (4), and pouzolignan J [1,4-dihydroxy-3-(3,5-dihydroxyphenyl) -2-[(3,4,5-trimethoxyphenyl)(4-hydroxy-3-methoxyphenyl)methyl]butane] (5), along with two known compounds, indolyl-3-carboxylic acid (6) and uracil (7), were isolated from the aerial parts of Pouzolzia zeylanica (L.) Benn. var. microphylla (Wedd.) W.T.Wang. The structures of these compounds were characterized based on spectroscopic methods, including IR, NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY), and HR-ESI/TOF-MS experiments. All the new norlignans were assayed for inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.

KEYWORDS:

Pouzolzia zeylanica (L.) Benn. var. microphylla (Wedd.) W.T.Wang; Urticaceae; nitric oxide inhibition; norlignans; pouzolignans F–J

PMID:
26067593
DOI:
10.1080/10286020.2015.1048685
[Indexed for MEDLINE]

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