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Curr Opin Cell Biol. 2015 Oct;36:1-6. doi: 10.1016/j.ceb.2015.05.003. Epub 2015 Jun 8.

Chemokine-guided cell positioning in the lymph node orchestrates the generation of adaptive immune responses.

Author information

1
Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.
2
Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States. Electronic address: aluster@mgh.harvard.edu.

Abstract

The generation of adaptive immune responses occurs in the lymph node (LN) and requires that lymphocytes locate and interact with cognate antigen-bearing dendritic cells. This process requires the coordinated movement of both innate and adaptive immune cells, and is orchestrated by the chemokine family of chemotactic cytokines. Upon initiation of inflammation, the LN undergoes dramatic changes that include the marked induction of specific chemokines in distinct regions of the reactive LN. These chemokine rich domains establish LN niches that facilitate the differentiation of CD4+ T cells into effector cell subsets and the rapid activation of memory CD8+ T cells. This review will focus on recent advances highlighting the importance of LN chemokines for shaping adaptive immune responses by controlling immune cell migration, positioning, and interactions in the reactive LN.

PMID:
26067148
PMCID:
PMC4639456
DOI:
10.1016/j.ceb.2015.05.003
[Indexed for MEDLINE]
Free PMC Article

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