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Physiol Behav. 2015 Dec 1;152(Pt B):363-71. doi: 10.1016/j.physbeh.2015.06.008. Epub 2015 Jun 9.

Effects of high-fat diet exposure on learning & memory.

Author information

1
Cellular & Molecular Medicine Graduate Program, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
2
Cellular & Molecular Medicine Graduate Program, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address: ktamashiro@jhmi.edu.

Abstract

The associations between consumption of a high-fat or 'Western' diet and metabolic disorders such as obesity, diabetes, and cardiovascular disease have long been recognized and a great deal of evidence now suggests that diets high in fat can also have a profound impact on the brain, behavior, and cognition. Here, we will review the techniques most often used to assess learning and memory in rodent models and discuss findings from studies assessing the cognitive effects of high-fat diet consumption. The review will then consider potential underlying mechanisms in the brain and conclude by reviewing emerging literature suggesting that maternal consumption of a high-fat diet may have effects on the learning and memory of offspring.

KEYWORDS:

Animal models; Behavior; Cognition; High-fat diet; Learning; Memory

PMID:
26066731
PMCID:
PMC5729745
DOI:
10.1016/j.physbeh.2015.06.008
[Indexed for MEDLINE]
Free PMC Article

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