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Arch Physiol Biochem. 2015;121(3):116-22. doi: 10.3109/13813455.2015.1038278. Epub 2015 Jun 12.

Investigation of antidiabetic action of Antidesma bunius extract in type 1 diabetes.

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1
National Organization for Drug Control and Research , Cairo , Egypt .

Abstract

CONTEXT:

Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant.

OBJECTIVES:

To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes.

MATERIALS AND METHODS:

A daily dose of A. bunius extract (250 mg/kg body weight) was given orally to alloxan-induced diabetic rats for 28 days. Blood glucose, insulin, TC, TG, amylase, lipase, liver glycogen were analysed.

RESULTS:

Extract revealed a significant reduction in blood glucose level (80.5%) along with an increase in serum insulin (134%), lipase (90.7%) and liver glycogen level (160%). Also amylase (28.2%) activity, TC (40.2%), and TG (28.8%) levels were significantly decreased when compared with diabetic control rats. A. bunius extract improved the histo-architectural of the β-cells.

DISCUSSION AND CONCLUSION:

The results suggested that A. bunius extract possess anti-diabetic activity, through the enhancement of hepatic glycogen storage and regeneration of the islet of Langerhans.

KEYWORDS:

Alloxan; TC; TG; insulin; liver glycogen

PMID:
26066546
DOI:
10.3109/13813455.2015.1038278
[Indexed for MEDLINE]

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