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J Reward Defic Syndr. 2015;1(1):24-35.

Using the Neuroadaptagen KB200z™ to Ameliorate Terrifying, Lucid Nightmares in RDS Patients: the Role of Enhanced, Brain-Reward, Functional Connectivity and Dopaminergic Homeostasis.

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Center for Psychiatric Medicine, North Andover, MA, USA.
Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA ; Department of Clinical Medicine, Malibu Beach Recovery Center, Malibu Beach, CA, USA ; Department of Addiction Medicine, Victory Nutrition International, LLC., Lederoch, PA, USA ; Community Mental Health Institute, Center for Clinical & Translational Science, University of Vermont and Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA ; Dominion Diagnostics, Inc. North Kingstown, RI, USA ; Center for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purbe Medinpur, West Bengal, India ; Center for RDS Research, Victory Nutrition, LLC, Austin, TX, USA ; Department of Nutrigenomics, RDSolutions, Inc., Salt Lake City, UT, USA ; Department of Personalized Medicine, IGENE, LLC., Austin, TX, USA.
Departments of Psychiatry, Anatomy and Neurobiology, and Boston VA and Boston University School of Medicine, MA, USA.
Department of Psychiatry and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA.
Department of Clinical Psychology and Addiction, Institute of Psychology, Eötvös Loránd University, Hungary.
Divisions of Addiction Services, & Applied Clinical Research & Education, Dominion Diagnostics, LLC, North Kingstown, RI, USA.
Departments of Psychiatry & Behavioral Sciences at the Keck, University of Southern California, School of Medicine, CA, USA ; Director of Research, Drug Enforcement Administration (DEA) Educational Foundation, Washington, D.C, USA.



Lucid Dreams are a form of dream life, during which the dreamer may be aware that he/she is dreaming, can stop/re-start the dreams, depending on the pleasantness or unpleasant nature of the dream, and experiences the dream as if he/she were fully awake. Depending on their content, they may be pleasant, un-pleasant or terrifying, at least in the context of patients, who also exhibit characteristics of Reward Deficiency Syndrome (RDS) and Posttraumatic Stress Disorder (PTSD).


We present eight clinical cases, with known substance abuse, childhood abuse and diagnosed PTSD/RDS. The administration of a putative dopamine agonist, KB200Z™, was associated with the elimination of unpleasant and/or terrifying, lucid dreams in 87.5% of the cases presented, whereas one very heavy cocaine abuser showed a minimal response. These results required the continuous use of this nutraceutical. The lucid dreams themselves were distinguishable from typical, PTSD nightmares insofar as their content did not appear to reflect a symbolic rendition of an originally-experienced, historical trauma. Each of the cases was diagnosed with a form of RDS, i.e., ADHD, ADD, and/or Tourette's syndrome. They all also suffered from some form of Post-Traumatic-Stress-Disorder (PTSD) and other psychiatric diagnoses as well.


The reduction or elimination of terrifying Lucid Dreams seemed to be dependent on KB220Z, whereby voluntary stopping of the agent results in reinstatement of the terrifying non-pleasant nature of the dreams. Following more required research on a much larger population we anticipate confirmation of these seemingly interesting observations. If these results in a small number of patients are indeed confirmed we may have found a frontline solution to a very perplexing and complicated symptom known as lucid dreams.


Functional brain connectivity; KB200Z; Lucid dreams; Nightmares; PTSD; Putative natural dopamine agonist

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